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活性蛋白

Recombinant Human Tumor-associated calcium signal transducer 2(TACSTD2),partial (Active): 恒遠生物蛋白表達平臺建立了從原核到真核四大重組表達系統(tǒng),并建立無細胞表達系統(tǒng),擁有基于昆蟲病毒外膜蛋白展示的蛋白表達技術(shù)、膜蛋白表達技術(shù)等一系列蛋白表達及純化技術(shù),有能力制備各種高難度蛋白。

產(chǎn)品詳情相關(guān)產(chǎn)品

Recombinant Human Tumor-associated calcium signal transducer 2(TACSTD2),partial (Active)

貨號：

HYB-10153
規(guī)格：
圖片：
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

產(chǎn)品詳情

純度：

Greater than 90% as determined by SDS-PAGE.
內(nèi)毒素：

Less than 1.0 EU/ug as determined by LAL method.
生物活性：

Measured in cell activity assay using U937 cells. The EC50 for this effect is 190.2-298.6 ng/ml.
基因名：

TACSTD2

別名：

Cell surface glycoprotein Trop 2; Cell surface glycoprotein Trop-2; Cell surface glycoprotein Trop2; Epithelial glycoprotein 1; GA733 1; GA7331; M1S 1; M1S1; Membrane component chromosome 1 surface marker 1; Pancreatic carcinoma marker protein GA733 1 ; Pancreatic carcinoma marker protein GA733-1; Pancreatic carcinoma marker protein GA7331 ; TACD 2; TACD2_HUMAN; TACSTD 2; Tacstd2; Trop 2; Trop2; Tumor associated calcium signal transducer 2 precursor ; Tumor-associated calcium signal transducer 2
分子結(jié)構(gòu)：
種屬：

Homo sapiens (Human)
蛋白長度：

Partial
來源：

Mammalian cell
分子量：

56.8 kDa
表達區(qū)域：

27-274aa
氨基酸序列

HTAAQDNCTCPTNKMTVCSPDGPGGRCQCRALGSGMAVDCSTLTSKCLLLKARMSAPKNARTLVRPSEHALVDNDGLYDPDCDPEGRFKARQCNQTSVCWCVNSVGVRRTDKGDLSLRCDELVRTHHILIDLRHRPTAGAFNHSDLDAELRRLFRERYRLHPKFVAAVHYEQPTIQIELRQNTSQKAAGDVDIGDAAYYFERDIKGESLFQGRGGLDLRVRGEPLQVERTLIYYLDEIPPKFSMKRLT
蛋白標簽：

C-terminal hFc-tagged
產(chǎn)品提供形式：

Liquid or Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
緩沖液：

Lyophilized from a 0.2 μm filtered PBS, 6% Trehalose, pH 7.4
儲存條件：

Store at -20°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質(zhì)期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.
產(chǎn)品描述：

With an EC50 between 190.2-298.6 ng/ml on U937 cells, Recombinant Human Tumor-Associated Calcium Signal Transducer 2 (TACSTD2) (also known as TROP2) finds application in various researches, including cancer research. This recombinant protein is a surface receptor with partial length. A DNA sequence encoding the TACSTD2 (27-274aa) was fused with an Fc-tag at C-terminal.
Overexpression and upregulation of TROP2 have been associated with various tumors and cancers. Its tumorigenic effects depend on ligand binding and the activation of intracellular pathways.
TROP2 is involved in the JAK/STAT pathway, MAP/ERK pathway, and the PI3/AKT pathway. It binds with ligands such as IGF-1, Cyclin, Claudin, and Protein Kinase C.
TROP2 also finds application in studies on gelatinous drop-like corneal dystrophy (GDLD). Mutations in the TACSTD2 gene have been shown to play a major role in the development of GDLD.
The purity and endotoxin levels of the Recombinant Human Tumor-Associated Calcium Signal Transducer 2 is determined using SDS-PAGE and LAL method, respectively. The product is over 90% pure with an endotoxin content below 1EU/μg.
Datasheet & COA：

Please contact us to get it.